Cychlorphine Research Standards & Analytical Data

Looking for cychlorphine analytical standards from verified chemical suppliers? We provide access to high-purity, laboratory-grade reference materials supported by complete documentation for qualification, assay, and research applications.

All materials are manufactured, tested, and packaged in strict compliance with ISO quality standards and are intended strictly for qualified laboratory and forensic analysis.

Request Reference Data & Availability

  • Request current pricing and batch sizing

  • Verify batch-specific analytical documentation

  • Access high-resolution spectra (NMR, LC-MS/MS, FTIR)

What is Cychlorphine?

Cychlorphine (N-propionitrile chlorphine; CAS No. 16145-71-4) is a novel synthetic opioid belonging to the piperidine benzimidazolone (orphine) subclass. Structurally distinct from fentanyl and nitazene derivatives, it acts primarily as a high-affinity $\mu$-opioid receptor agonist, with demonstrated activity at $\kappa$– and $\delta$-opioid receptors.

Recent pharmacological characterization indicates that cychlorphine exhibits extreme potency—significantly exceeding fentanyl in preliminary in vivo models—requiring controlled, sub-milligram handling protocols in research environments.

Technical Specifications & Chemical Data

Parameter Specification
IUPAC Name 3-[3-[1-[1-(4-chlorophenyl)ethyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]propanenitrile
CAS Number 16145-71-4
Chemical Formula $\text{C}_{23}\text{H}_{25}\text{ClN}_4\text{O}$
Molecular Weight 408.93 g/mol
Chemical Class Benzimidazolone / Orphine Opioid Analogue
Form Crystalline solid / Analytical powder standard

Applications in Analytical & Toxicological Research

Due to the emergence of novel synthetic opioids (NSOs) in forensic and epidemiological samples, accurate analytical standards are critical. Researchers seek cychlorphine standards primarily for:

  • Forensic Screening & Toxicology: Developing LC-MS/MS, LC-QTOF-MS, and GC-MS retention indices and library spectra.

  • Receptor Binding Kinetics: Assaying binding affinity ($K_i$) and functional activation ($\text{EC}_{50}$) across opioid receptor subtypes.

  • Metabolite Identification: Mapping in vitro hepatic microsomal metabolism to identify target biomarkers for clinical detection.

Quality Assurance & Certificate of Analysis (COA)

When evaluating reference materials, verifying batch purity is vital for reproducible experimental data. Every reference standard batch includes:

  • Third-Party Certificate of Analysis (COA) with verified assay percentage ($\ge 98\%$ purity).

  • Proton Nuclear Magnetic Resonance ($^1\text{H-NMR}$) characterization spectra.

  • Liquid Chromatography-Mass Spectrometry (LC-MS) confirmation data.

  • Batch-Specific Traceability and safety data sheets (SDS).

Safety, Toxicity, & Handling Guidelines

Warning: Cychlorphine is an extremely potent compound with limited comprehensive toxicological data. It presents severe risks of respiratory depression upon exposure.

  • Strictly Prohibited: Not for human, veterinary, therapeutic, or diagnostic use.

  • PPE Requirements: Handle exclusively within certified chemical fume hoods using nitrile gloves, eye protection, and full lab coat coverage.

  • Storage Conditions: Store in desiccated, airtight containers at $-20^\circ\text{C}$ protected from light to maintain long-term chemical stability.

Legal & Regulatory Compliance

Cychlorphine is subject to varying regulatory frameworks internationally:

  • Germany: Listed under the Neue-psychoaktive-Stoffe-Gesetz (NpSG).

  • International Oversight: Under monitoring by the UNODC Early Warning Advisory and regional public health authorities.

  • Buyer Verification: Verification of institutional credentials, local regulatory authorization, and valid end-user declarations are mandatory prior to dispatch.

Frequently Asked Questions

How is cychlorphine identified in unknown samples?

Standard immunoassay drug screens typically fail to detect cychlorphine. Definitive identification requires advanced chromatographic methods such as LC-MS/MS or high-resolution LC-QTOF-MS utilizing verified reference spectra.

Is cychlorphine structurally related to morphine or fentanyl?

No. Despite the “-orphine” suffix, it is a piperidine benzimidazolone derivative, placing it in the orphine class alongside compounds like brorphine and spirochlorphine rather than traditional morphinans or phenethylpiperidines.