Cychlorphine: Wholesale Cychlorphine Powder for Sale 

Cychlorphine powder for sale at the most competitive prices, (N-Propionitrile Chlorphine) hydrochloride is a potent μ-opioid receptor (MOP) agonist. Cychlorphine hydrochloride produces analgesic effects. Cychlorphine hydrochloride induces respiratory depression and exhibits complex reversal kinetics with Naloxone (HY-17417A). Cychlorphine hydrochloride can be used for research on opioid overdose.

What Is Cychlorphine?

Cychlorphine is a synthetic opioid chemical compound which has been sold as a designer drug, reported in five European countries since 2024, and in the United States. It has been found in Canada as of September 2025.[2] In Denmark, it has been found among confiscated drugs and in an autopsy of a person who died of a drug overdose. It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine have been published. It is not a structural analog of morphine, despite the similar name. Instead, it is an orphine.Furthermore, it has been detected as the sole active opioid in fake pharmaceutical opioid preparations that are supposed to contain hydromorphone or oxycodone, further increasing the risk of accidental overdoses.[2] In July 2026, cyclorphine was detected in a fake nutritional supplement sold as Lion’s Mane.

Cychlorphine Powder for sale 

CAS Number:

16145-71-4

Purity:

≥98%

Formulation:

A solid

Molecular Formula:

C23H25ClN4O • HCl

Molecular Weight:

445.3843

Mass Spectrometry:

Analytical Standards

Alternative Names:

3-[1-[1-(4-chlorophenyl)ethyl]-4-piperidinyl]-2,3-dihydro-2-oxo-1h-benzimidazole-1-propanenitrile, monohydrochloride, cychlorphine

Cychlorphine Chemical Structure

Cychlorphine (N-propionitrile chlorphine) is structurally defined by a central piperidine ring bridged between a substituted benzimidazolone core and a phenethyl moiety. Specifically, it features a 4-chlorophenyl group at the ethyl tail and a cyanoethyl (N-propionitrile) chain attached to the benzimidazolone nitrogen. This nitrile substitution distinguishes it from parent compounds in the same chemical family, directly modifying its lipophilicity and target binding profile.

 

How Cychlorphine Relates to Synthetic Opioids

 

Cychlorphine belongs to the piperidine benzimidazolone subclass, colloquially known as “orphines”. It is a non-fentanyl, non-nitazene synthetic opioid.
  • Distinct Scaffold: Unlike fentanyls (4-anilidopiperidines) or nitazenes (benzimidazoles like isotonitazene), cychlorphine shares a core framework with historical research compounds like bezitramide and modern analogues like brorphine.
  • Market Shift: Following increased international regulation surrounding nitazene derivatives, illicit manufacturing has increasingly pivoted toward benzimidazolone scaffolds like cychlorphine.
Cychlorphine Pharmacology
Primary pharmacodynamic data indicates that cychlorphine functions as a potent agonist at the $\mu$-opioid receptor (MOR).
  • Receptor Affinity: Preclinical assays demonstrate high nanomolar binding affinity to MOR, triggering typical downstream pathways including G-protein activation and $\beta$-arrestin recruitment.
  • Potency: Laboratory estimates and observational toxicology place cychlorphine’s potency comparable to, or significantly exceeding, that of fentanyl.
  • Reversal Profile: Animal studies on related benzimidazolone analogues highlight complex receptor dissociation kinetics, where standard opioid antagonists like naloxone may exhibit reduced efficiency or require higher, repeated dosing to reverse respiratory depression.
(For further details on related structural families, explore our guides on Brorphine & Benzimidazolones, Nitazene Analogues Overview, Non-Fentanyl Opioid Agonists, and Opioid Receptor Binding Dynamics.)

 

Cychlorphine Toxicology and Safety

As an uncontrolled novelty agonist, cychlorphine presents severe toxicological risks, including rapid-onset respiratory depression, CNS depression, and fatal overdose. It is frequently detected as an adulterant in counterfeit prescription opioids (e.g., fake oxycodone or hydromorphone) and other illicit powders.For an in-depth breakdown of metabolic pathways, detection thresholds, and clinical management strategies, visit our detailed Cychlorphine Toxicology & Health Risks page.

Cychlorphine Research

Current scientific literature on cychlorphine is restricted to forensic analysis, early-warning network drug monitoring (such as CFSRE and UNODC bulletins), and qualitative structure-activity relationship (SAR) mapping. No human clinical trials exist, and the substance remains purely a research chemical used for analytical reference and toxicological surveillance.

Cychlorphine Legal and Regulatory Status

Cychlorphine is not approved for medical or veterinary use anywhere globally. Authorities across North America and Europe have moved to place it under emergency temporary scheduling and national controlled substance lists (such as Schedule I proposals in the US and NpSG additions in Europe).
A comprehensive breakdown of international jurisdiction laws can be found in our Cychlorphine Regulatory & Legal Status article.

Frequently Asked Questions

What class of drug is cychlorphine?
Cychlorphine is a novel synthetic opioid (NSO) belonging to the piperidine benzimidazolone (“orphine”) structural class.
Is cychlorphine a nitazene or a fentanyl analogue?
No. While it produces similar opioid effects, it has a distinct benzimidazolone chemical structure separate from both fentanyl and nitazene scaffolds.
How is cychlorphine detected in laboratory samples?

It is typically identified using high-resolution liquid chromatography-mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) targeted screening in forensic laboratories.

References

  1.  Sprague JE, Toms JA, Ratermann CF (December 2025). “Non-fatal opioid overdose associated predominantly with the benzimidazolone, cychlorphine”. Clinical Toxicology. Philadelphia, Pa.: 1–2. doi:10.1080/15563650.2025.2594070. PMID 41347459.
  2.  Alevato J (November 4, 2025). “A new opioid has been found in Toronto’s drug supply and users may not even know it”. CBC.ca. Retrieved December 7, 2025.
  3.  “Sundhedsstyrelsen advarer: Stærkt opioid fundet i Danmark”. DR (in Danish). 2026-07-31. Retrieved 2026-07-31.
  4.  “Chlorphine” (PDF). NPS Discovery — New Drug Monograph. The Center for Forensic Science Research & Education (CSFRE).
  5.  “European Drug Report 2025 – Full Book” (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.
  6.  US 3318900, Janssen PA, “Derivatives of benzimidazolinyl piperidine”, issued 9 May 1967, assigned to Janssen Pharmaceutica NV
  7.  “Increase in Fatal Overdoses Linked to Novel Synthetic Opioid N-Propionitrile Chlorphine (Cychlorphine)”. The Center for Forensic Science Research & Education. January 30, 2026